Self‐assembly of multi‐component mitochondrial nucleoids via phase separation
نویسندگان
چکیده
منابع مشابه
Phase Separation in Multicomponent Aqueous-Protein Solutions
published in Advance ACS Abstracts, December 1, 1994. 0022-3654/95/2099-0454$09.00/0 we present here the results of experimental and theoretical studies of a ternary solution constituted of the proteins yma (designated as protein A), a “high-Tc” protein, and yw (designated as protein B), a “low-Tc” protein, in aqueous solution. The solution pH was kept constant at 7.1 by a 100 mM phosphate buff...
متن کاملCoarsening rates for models of multicomponent phase separation
We study the coarsening of solutions of two models of multicomponent phase separation. One is a constant mobility system; the other is a degenerate mobility system. These models are natural generalizations of the Cahn-Hilliard equation to the case of a vector-valued order parameter. It has been conjectured that the characteristic length scale `(t) grows like t as t→∞ for the first case and ` ∼ ...
متن کاملDigital holographic microscopy of phase separation in multicomponent lipid membranes.
Lateral in-homogeneities in lipid compositions cause microdomains formation and change in the physical properties of biological membranes. With the presence of cholesterol and mixed species of lipids, phospholipid membranes segregate into lateral domains of liquid-ordered and liquid-disordered phases. Coupling of two-dimensional intralayer phase separations and interlayer liquid-crystalline ord...
متن کاملComposition and dynamics of human mitochondrial nucleoids.
The organization of multiple mitochondrial DNA (mtDNA) molecules in discrete protein-DNA complexes called nucleoids is well studied in Saccharomyces cerevisiae. Similar structures have recently been observed in human cells by the colocalization of a Twinkle-GFP fusion protein with mtDNA. However, nucleoids in mammalian cells are poorly characterized and are often thought of as relatively simple...
متن کاملOrganization and dynamics of yeast mitochondrial nucleoids
Mitochondrial DNA (mtDNA) is packaged by association with specific proteins in compact DNA-protein complexes named mitochondrial nucleoids (mt-nucleoids). The budding yeast Saccharomyces cerevisiae is able to grow either aerobically or anaerobically. Due to this characteristic, S. cerevisiae has been extensively used as a model organism to study genetics, morphology and biochemistry of mitochon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2021
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2020107165